Drug interactions
Amlodipine + Cisatracurium
Severity: Minor
Amlodipine and Cisatracurium: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Calcium channel blockers may modestly enhance and prolong neuromuscular blockade from nondepolarizing agents such as cisatracurium. The effect is usually small, but recovery may be slower than expected.
What this interaction means in plain words
Amlodipine and Cisatracurium have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amlodipine belongs to Cardiovascular; Cisatracurium belongs to Musculoskeletal.
Why it happens
Calcium channel blockade may reduce presynaptic acetylcholine release and add to postsynaptic nondepolarizing blockade.
What to do
Monitor neuromuscular function with train-of-four and titrate cisatracurium to effect. Be prepared for slower recovery.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cisatracurium
Other interactions of Amlodipine
- Amifostine + Amlodipine Major
- Amlodipine + Ombitasvir / paritaprevir / ritonavir and dasabuvir Major
- Activated Charcoal + Amlodipine Moderate
- Aldesleukin + Amlodipine Moderate
- Alfuzosin + Amlodipine Moderate
- Amlodipine + Apalutamide Moderate
Frequently asked questions
Can I take Amlodipine with Cisatracurium?
MediHelp rates the interaction as minor. Amlodipine and Cisatracurium have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Calcium channel blockers may modestly enhance and prolong neuromuscular blockade from nondepolarizing agents such as cisatracurium. The effect is usually small, but recovery may be slower than expected.
How serious is the interaction between Amlodipine and Cisatracurium?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor neuromuscular function with train-of-four and titrate cisatracurium to effect. Be prepared for slower recovery.
What other medicines interact with Cisatracurium?
MediHelp also lists interactions of Cisatracurium with, for example, Amikacin, Bacitracin-neomycin-polymyxin, Benzhydrocodone / acetaminophen. The full list is on the Cisatracurium page.
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