Drug interactions
Amlodipine + Felodipine
Severity: Moderate
Amlodipine and Felodipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are dihydropyridine calcium channel blockers, so combining them duplicates therapy and adds vasodilatory effects. This can cause excessive hypotension, reflex tachycardia, headache and peripheral edema without added benefit.
What this interaction means in plain words
Amlodipine and Felodipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine belongs to Cardiovascular; Felodipine belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic L-type calcium channel blockade within the same drug class.
What to do
Avoid using two dihydropyridines together; choose one agent and titrate it. If both were given, monitor blood pressure, heart rate and edema.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine
- Amifostine + Amlodipine Major
- Amlodipine + Ombitasvir / paritaprevir / ritonavir and dasabuvir Major
- Activated Charcoal + Amlodipine Moderate
- Aldesleukin + Amlodipine Moderate
- Alfuzosin + Amlodipine Moderate
- Amlodipine + Apalutamide Moderate
Other interactions of Felodipine
- Felodipine + Itraconazole Contraindicated
- Aldesleukin + Felodipine Major
- Amifostine + Felodipine Major
- Apalutamide + Felodipine Major
- Atazanavir + Felodipine Major
- Carbamazepine + Felodipine Major
Frequently asked questions
Can I take Amlodipine with Felodipine?
MediHelp rates the interaction as moderate. Amlodipine and Felodipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs are dihydropyridine calcium channel blockers, so combining them duplicates therapy and adds vasodilatory effects. This can cause excessive hypotension, reflex tachycardia, headache and peripheral edema without added benefit.
How serious is the interaction between Amlodipine and Felodipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid using two dihydropyridines together; choose one agent and titrate it. If both were given, monitor blood pressure, heart rate and edema.
What other medicines interact with Amlodipine?
MediHelp also lists interactions of Amlodipine with, for example, Amifostine, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Activated Charcoal. The full list is on the Amlodipine page.
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