Drug interactions
Amlodipine + Levodopa
Severity: Moderate
Amlodipine and Levodopa: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levodopa can cause orthostatic hypotension, and combining it with an antihypertensive such as amlodipine may add to the blood pressure lowering. Patients may have dizziness or falls, particularly when treatment is started or doses are raised.
What this interaction means in plain words
Amlodipine and Levodopa can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine belongs to Cardiovascular; Levodopa belongs to Central Nervous System.
Why it happens
Additive hypotensive pharmacodynamic effects of dopamine-derived vasodilation and calcium channel blockade.
What to do
Check sitting and standing blood pressure when either drug is started or adjusted. Lower the amlodipine dose if symptomatic orthostasis occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine
- Amifostine + Amlodipine Major
- Amlodipine + Ombitasvir / paritaprevir / ritonavir and dasabuvir Major
- Activated Charcoal + Amlodipine Moderate
- Aldesleukin + Amlodipine Moderate
- Alfuzosin + Amlodipine Moderate
- Amlodipine + Apalutamide Moderate
Other interactions of Levodopa
- Isocarboxazid + Levodopa Contraindicated
- Levodopa + Phenelzine Contraindicated
- Levodopa + Phenelzine (nonselective MAOI) Contraindicated
- Levodopa + Procarbazine Contraindicated
- Levodopa + Tranylcypromine Contraindicated
- Amisulpride + Levodopa Major
Frequently asked questions
Can I take Amlodipine with Levodopa?
MediHelp rates the interaction as moderate. Amlodipine and Levodopa can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Levodopa can cause orthostatic hypotension, and combining it with an antihypertensive such as amlodipine may add to the blood pressure lowering. Patients may have dizziness or falls, particularly when treatment is started or doses are raised.
How serious is the interaction between Amlodipine and Levodopa?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check sitting and standing blood pressure when either drug is started or adjusted. Lower the amlodipine dose if symptomatic orthostasis occurs.
What other medicines interact with Amlodipine?
MediHelp also lists interactions of Amlodipine with, for example, Amifostine, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Activated Charcoal. The full list is on the Amlodipine page.
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