Drug interactions
Amlodipine + Pancuronium
Severity: Minor
Amlodipine and Pancuronium: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Calcium channel blockers may modestly enhance and prolong the neuromuscular blockade produced by non-depolarising agents such as pancuronium. The effect is usually small but can lengthen recovery time.
What this interaction means in plain words
Amlodipine and Pancuronium have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amlodipine belongs to Cardiovascular; Pancuronium belongs to Musculoskeletal.
Why it happens
Calcium channel blockade reduces presynaptic calcium-dependent acetylcholine release, adding to postsynaptic nicotinic receptor blockade.
What to do
Monitor neuromuscular function with train-of-four during anaesthesia and titrate pancuronium to effect.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Pancuronium
Other interactions of Amlodipine
- Amifostine + Amlodipine Major
- Amlodipine + Ombitasvir / paritaprevir / ritonavir and dasabuvir Major
- Activated Charcoal + Amlodipine Moderate
- Aldesleukin + Amlodipine Moderate
- Alfuzosin + Amlodipine Moderate
- Amlodipine + Apalutamide Moderate
Frequently asked questions
Can I take Amlodipine with Pancuronium?
MediHelp rates the interaction as minor. Amlodipine and Pancuronium have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Calcium channel blockers may modestly enhance and prolong the neuromuscular blockade produced by non-depolarising agents such as pancuronium. The effect is usually small but can lengthen recovery time.
How serious is the interaction between Amlodipine and Pancuronium?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor neuromuscular function with train-of-four during anaesthesia and titrate pancuronium to effect.
What other medicines interact with Pancuronium?
MediHelp also lists interactions of Pancuronium with, for example, Amikacin, Bacitracin-neomycin-polymyxin, Capreomycin. The full list is on the Pancuronium page.
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