Drug interactions
Amlodipine-atorvastatin + Artemether / lumefantrine
Severity: Minor
Amlodipine-atorvastatin and Artemether / lumefantrine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Artemether is a weak CYP3A4 inducer and may modestly lower amlodipine and atorvastatin levels. Lumefantrine is a CYP3A4 substrate and the clinical effect is likely small during a short malaria course.
What this interaction means in plain words
Amlodipine-atorvastatin and Artemether / lumefantrine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Artemether weakly induces CYP3A4, increasing metabolism of amlodipine and atorvastatin.
What to do
No routine change is needed for a short course. Monitor blood pressure if the antimalarial is given for several days.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amlodipine-atorvastatin
Frequently asked questions
Can I take Amlodipine-atorvastatin with Artemether / lumefantrine?
MediHelp rates the interaction as minor. Amlodipine-atorvastatin and Artemether / lumefantrine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Artemether is a weak CYP3A4 inducer and may modestly lower amlodipine and atorvastatin levels. Lumefantrine is a CYP3A4 substrate and the clinical effect is likely small during a short malaria course.
How serious is the interaction between Amlodipine-atorvastatin and Artemether / lumefantrine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed for a short course. Monitor blood pressure if the antimalarial is given for several days.
What other medicines interact with Amlodipine-atorvastatin?
MediHelp also lists interactions of Amlodipine-atorvastatin with, for example, Amifostine, Apalutamide, Atazanavir. The full list is on the Amlodipine-atorvastatin page.
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