Drug interactions
Amlodipine-atorvastatin + Bretylium
Severity: Moderate
Amlodipine-atorvastatin and Bretylium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bretylium commonly causes hypotension through adrenergic neuron blockade, and amlodipine may worsen this. The combination can produce significant blood pressure drops in patients receiving bretylium for arrhythmias.
What this interaction means in plain words
Amlodipine-atorvastatin and Bretylium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hypotension from adrenergic neuron blockade and peripheral vasodilation.
What to do
Monitor blood pressure closely during bretylium therapy and consider holding or reducing amlodipine if hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-atorvastatin
Frequently asked questions
Can I take Amlodipine-atorvastatin with Bretylium?
MediHelp rates the interaction as moderate. Amlodipine-atorvastatin and Bretylium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bretylium commonly causes hypotension through adrenergic neuron blockade, and amlodipine may worsen this. The combination can produce significant blood pressure drops in patients receiving bretylium for arrhythmias.
How serious is the interaction between Amlodipine-atorvastatin and Bretylium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure closely during bretylium therapy and consider holding or reducing amlodipine if hypotension occurs.
What other medicines interact with Amlodipine-atorvastatin?
MediHelp also lists interactions of Amlodipine-atorvastatin with, for example, Amifostine, Apalutamide, Atazanavir. The full list is on the Amlodipine-atorvastatin page.
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