Drug interactions
Amlodipine-atorvastatin + Dabrafenib
Severity: Moderate
Amlodipine-atorvastatin and Dabrafenib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dabrafenib induces CYP3A4, which can lower plasma concentrations of both amlodipine and atorvastatin. Blood pressure control and lipid lowering may become less effective during combined use.
What this interaction means in plain words
Amlodipine-atorvastatin and Dabrafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-atorvastatin belongs to Cardiovascular; Dabrafenib belongs to Oncology.
Why it happens
Dabrafenib induces CYP3A4 (and other enzymes), increasing the metabolism of amlodipine and atorvastatin.
What to do
Monitor blood pressure and lipid response while dabrafenib is taken and after it is stopped. Increase the antihypertensive or statin dose if control is lost, or consider an alternative agent.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-atorvastatin
Other interactions of Dabrafenib
Frequently asked questions
Can I take Amlodipine-atorvastatin with Dabrafenib?
MediHelp rates the interaction as moderate. Amlodipine-atorvastatin and Dabrafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dabrafenib induces CYP3A4, which can lower plasma concentrations of both amlodipine and atorvastatin. Blood pressure control and lipid lowering may become less effective during combined use.
How serious is the interaction between Amlodipine-atorvastatin and Dabrafenib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and lipid response while dabrafenib is taken and after it is stopped. Increase the antihypertensive or statin dose if control is lost, or consider an alternative agent.
What other medicines interact with Amlodipine-atorvastatin?
MediHelp also lists interactions of Amlodipine-atorvastatin with, for example, Amifostine, Apalutamide, Atazanavir. The full list is on the Amlodipine-atorvastatin page.
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