Drug interactions
Amlodipine-atorvastatin + Diltiazem
Severity: Moderate
Amlodipine-atorvastatin and Diltiazem: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Diltiazem inhibits CYP3A4 and increases exposure to amlodipine and atorvastatin. This can cause more hypotension, edema and dizziness, and may raise the risk of statin-related myopathy. Combining a dihydropyridine with diltiazem is sometimes done deliberately but needs oversight.
What this interaction means in plain words
Amlodipine-atorvastatin and Diltiazem can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-atorvastatin belongs to Cardiovascular; Diltiazem belongs to Cardiovascular.
Why it happens
Diltiazem inhibits CYP3A4 and reduces first-pass and systemic clearance of amlodipine and atorvastatin.
What to do
Monitor blood pressure, heart rate and edema, and reduce the amlodipine dose if hypotension occurs. Counsel the patient to report muscle pain, and use the lowest effective atorvastatin dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-atorvastatin
Other interactions of Diltiazem
- Diltiazem + Flibanserin Contraindicated
- Diltiazem + Ivabradine Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Diltiazem + Lonafarnib Contraindicated
- Acebutolol + Diltiazem Major
- Alfentanil + Diltiazem Major
Frequently asked questions
Can I take Amlodipine-atorvastatin with Diltiazem?
MediHelp rates the interaction as moderate. Amlodipine-atorvastatin and Diltiazem can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Diltiazem inhibits CYP3A4 and increases exposure to amlodipine and atorvastatin. This can cause more hypotension, edema and dizziness, and may raise the risk of statin-related myopathy. Combining a dihydropyridine with diltiazem is sometimes done deliberately but needs oversight.
How serious is the interaction between Amlodipine-atorvastatin and Diltiazem?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate and edema, and reduce the amlodipine dose if hypotension occurs. Counsel the patient to report muscle pain, and use the lowest effective atorvastatin dose.
What other medicines interact with Amlodipine-atorvastatin?
MediHelp also lists interactions of Amlodipine-atorvastatin with, for example, Amifostine, Apalutamide, Atazanavir. The full list is on the Amlodipine-atorvastatin page.
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