Drug interactions
Amlodipine-atorvastatin + Erythromycin stearate
Severity: Moderate
Amlodipine-atorvastatin and Erythromycin stearate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erythromycin inhibits CYP3A4 and can raise amlodipine and atorvastatin levels. This may cause hypotension or edema from amlodipine, and a higher risk of myopathy from atorvastatin.
What this interaction means in plain words
Amlodipine-atorvastatin and Erythromycin stearate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Erythromycin inhibits CYP3A4, reducing metabolism of amlodipine and atorvastatin.
What to do
Monitor blood pressure and watch for muscle pain or weakness; consider temporarily holding atorvastatin during a short course, or use azithromycin instead.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-atorvastatin
Frequently asked questions
Can I take Amlodipine-atorvastatin with Erythromycin stearate?
MediHelp rates the interaction as moderate. Amlodipine-atorvastatin and Erythromycin stearate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Erythromycin inhibits CYP3A4 and can raise amlodipine and atorvastatin levels. This may cause hypotension or edema from amlodipine, and a higher risk of myopathy from atorvastatin.
How serious is the interaction between Amlodipine-atorvastatin and Erythromycin stearate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and watch for muscle pain or weakness; consider temporarily holding atorvastatin during a short course, or use azithromycin instead.
What other medicines interact with Amlodipine-atorvastatin?
MediHelp also lists interactions of Amlodipine-atorvastatin with, for example, Amifostine, Apalutamide, Atazanavir. The full list is on the Amlodipine-atorvastatin page.
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