Drug interactions
Amlodipine-atorvastatin + Fosamprenavir
Severity: Major
Amlodipine-atorvastatin and Fosamprenavir: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fosamprenavir, whose active form amprenavir inhibits CYP3A4 (more so when boosted with ritonavir), can raise exposure to amlodipine and atorvastatin. This increases the risk of hypotension, edema and statin myopathy.
What this interaction means in plain words
Amlodipine-atorvastatin and Fosamprenavir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Amprenavir inhibits CYP3A4, reducing clearance of amlodipine and atorvastatin.
What to do
Use the lowest effective atorvastatin dose and monitor for muscle symptoms; monitor blood pressure and reduce the amlodipine dose if needed.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Amlodipine-atorvastatin and Fosamprenavir, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
References
Other interactions of Amlodipine-atorvastatin
Frequently asked questions
Can I take Amlodipine-atorvastatin with Fosamprenavir?
MediHelp rates the interaction as major. Amlodipine-atorvastatin and Fosamprenavir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Fosamprenavir, whose active form amprenavir inhibits CYP3A4 (more so when boosted with ritonavir), can raise exposure to amlodipine and atorvastatin. This increases the risk of hypotension, edema and statin myopathy.
How serious is the interaction between Amlodipine-atorvastatin and Fosamprenavir?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective atorvastatin dose and monitor for muscle symptoms; monitor blood pressure and reduce the amlodipine dose if needed.
What other medicines interact with Amlodipine-atorvastatin?
MediHelp also lists interactions of Amlodipine-atorvastatin with, for example, Amifostine, Apalutamide, Atazanavir. The full list is on the Amlodipine-atorvastatin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
