Drug interactions
Amlodipine-atorvastatin + Grapefruit
Severity: Moderate
Amlodipine-atorvastatin and Grapefruit: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Grapefruit juice inhibits intestinal CYP3A4 and can raise atorvastatin levels, especially with large quantities. Amlodipine is affected only slightly.
What this interaction means in plain words
Amlodipine-atorvastatin and Grapefruit can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Furanocoumarins in grapefruit inhibit intestinal CYP3A4, reducing first-pass metabolism.
What to do
Advise avoiding large amounts of grapefruit juice (over about 1.2 L daily). Counsel patients to report muscle pain or weakness.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-atorvastatin
Frequently asked questions
Can I take Amlodipine-atorvastatin with Grapefruit?
MediHelp rates the interaction as moderate. Amlodipine-atorvastatin and Grapefruit can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Grapefruit juice inhibits intestinal CYP3A4 and can raise atorvastatin levels, especially with large quantities. Amlodipine is affected only slightly.
How serious is the interaction between Amlodipine-atorvastatin and Grapefruit?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise avoiding large amounts of grapefruit juice (over about 1.2 L daily). Counsel patients to report muscle pain or weakness.
What other medicines interact with Amlodipine-atorvastatin?
MediHelp also lists interactions of Amlodipine-atorvastatin with, for example, Amifostine, Apalutamide, Atazanavir. The full list is on the Amlodipine-atorvastatin page.
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