Drug interactions
Amlodipine-atorvastatin + Isradipine
Severity: Moderate
Amlodipine-atorvastatin and Isradipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are dihydropyridine calcium channel blockers, so combining them duplicates therapy. This adds vasodilatory adverse effects such as hypotension, flushing, headache and edema without clear added benefit.
What this interaction means in plain words
Amlodipine-atorvastatin and Isradipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Duplicate L-type calcium channel blockade causing additive vasodilation.
What to do
Avoid combining two dihydropyridines; use a single agent and adjust its dose. If both are given, monitor blood pressure and edema.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Amlodipine-atorvastatin and Isradipine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Amlodipine-atorvastatin
Frequently asked questions
Can I take Amlodipine-atorvastatin with Isradipine?
MediHelp rates the interaction as moderate. Amlodipine-atorvastatin and Isradipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both are dihydropyridine calcium channel blockers, so combining them duplicates therapy. This adds vasodilatory adverse effects such as hypotension, flushing, headache and edema without clear added benefit.
How serious is the interaction between Amlodipine-atorvastatin and Isradipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining two dihydropyridines; use a single agent and adjust its dose. If both are given, monitor blood pressure and edema.
What other medicines interact with Amlodipine-atorvastatin?
MediHelp also lists interactions of Amlodipine-atorvastatin with, for example, Amifostine, Apalutamide, Atazanavir. The full list is on the Amlodipine-atorvastatin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
