Drug interactions
Amlodipine-atorvastatin + Nitroglycerin rectal
Severity: Moderate
Amlodipine-atorvastatin and Nitroglycerin rectal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Organic nitrates and calcium channel blockers both vasodilate, and together may cause marked orthostatic hypotension. This may lead to dizziness, syncope and reduced coronary perfusion.
What this interaction means in plain words
Amlodipine-atorvastatin and Nitroglycerin rectal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive vasodilation through nitric oxide mediated venodilation and calcium channel blockade.
What to do
Monitor blood pressure and orthostatic symptoms, and counsel on rising slowly. Reduce the dose of one agent if hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-atorvastatin
Frequently asked questions
Can I take Amlodipine-atorvastatin with Nitroglycerin rectal?
MediHelp rates the interaction as moderate. Amlodipine-atorvastatin and Nitroglycerin rectal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Organic nitrates and calcium channel blockers both vasodilate, and together may cause marked orthostatic hypotension. This may lead to dizziness, syncope and reduced coronary perfusion.
How serious is the interaction between Amlodipine-atorvastatin and Nitroglycerin rectal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms, and counsel on rising slowly. Reduce the dose of one agent if hypotension occurs.
What other medicines interact with Amlodipine-atorvastatin?
MediHelp also lists interactions of Amlodipine-atorvastatin with, for example, Amifostine, Apalutamide, Atazanavir. The full list is on the Amlodipine-atorvastatin page.
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