Drug interactions
Amlodipine-atorvastatin + Ombitasvir / paritaprevir / ritonavir and dasabuvir
Severity: Major
Amlodipine-atorvastatin and Ombitasvir / paritaprevir / ritonavir and dasabuvir: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
This regimen contains ritonavir and paritaprevir, which inhibit CYP3A4 and raise amlodipine exposure. Atorvastatin exposure is also increased, raising the risk of myopathy and rhabdomyolysis.
What this interaction means in plain words
Amlodipine-atorvastatin and Ombitasvir / paritaprevir / ritonavir and dasabuvir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Ritonavir-boosted CYP3A4 inhibition, with additional OATP inhibition by paritaprevir, increases amlodipine and atorvastatin concentrations.
What to do
Avoid the fixed-dose combination and use separate agents; reduce the amlodipine dose by at least half and hold atorvastatin during therapy. Monitor for hypotension, edema and muscle symptoms.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Amlodipine-atorvastatin
Frequently asked questions
Can I take Amlodipine-atorvastatin with Ombitasvir / paritaprevir / ritonavir and dasabuvir?
MediHelp rates the interaction as major. Amlodipine-atorvastatin and Ombitasvir / paritaprevir / ritonavir and dasabuvir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. This regimen contains ritonavir and paritaprevir, which inhibit CYP3A4 and raise amlodipine exposure. Atorvastatin exposure is also increased, raising the risk of myopathy and rhabdomyolysis.
How serious is the interaction between Amlodipine-atorvastatin and Ombitasvir / paritaprevir / ritonavir and dasabuvir?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the fixed-dose combination and use separate agents; reduce the amlodipine dose by at least half and hold atorvastatin during therapy. Monitor for hypotension, edema and muscle symptoms.
What other medicines interact with Amlodipine-atorvastatin?
MediHelp also lists interactions of Amlodipine-atorvastatin with, for example, Amifostine, Apalutamide, Atazanavir. The full list is on the Amlodipine-atorvastatin page.
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