Drug interactions
Amlodipine-atorvastatin + Phenytoin
Severity: Moderate
Amlodipine-atorvastatin and Phenytoin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenytoin can induce metabolism of amlodipine and atorvastatin, lowering their effect. Amlodipine has been reported to affect phenytoin levels, but the clinical importance is uncertain.
What this interaction means in plain words
Amlodipine-atorvastatin and Phenytoin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-atorvastatin belongs to Cardiovascular; Phenytoin belongs to Central Nervous System.
Why it happens
Phenytoin induces CYP3A4, increasing amlodipine and atorvastatin clearance; effects of amlodipine on phenytoin are not well established.
What to do
Monitor blood pressure and lipid response, and check phenytoin levels and signs of toxicity when amlodipine is started or changed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Amlodipine-atorvastatin and Phenytoin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Amlodipine-atorvastatin
Other interactions of Phenytoin
- Artemether / lumefantrine + Phenytoin Contraindicated
- Bictegravir + Phenytoin Contraindicated
- Cabotegravir + Phenytoin Contraindicated
- Doravirine + Phenytoin Contraindicated
- Elbasvir / grazoprevir + Phenytoin Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Phenytoin Contraindicated
Frequently asked questions
Can I take Amlodipine-atorvastatin with Phenytoin?
MediHelp rates the interaction as moderate. Amlodipine-atorvastatin and Phenytoin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Phenytoin can induce metabolism of amlodipine and atorvastatin, lowering their effect. Amlodipine has been reported to affect phenytoin levels, but the clinical importance is uncertain.
How serious is the interaction between Amlodipine-atorvastatin and Phenytoin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and lipid response, and check phenytoin levels and signs of toxicity when amlodipine is started or changed.
What other medicines interact with Amlodipine-atorvastatin?
MediHelp also lists interactions of Amlodipine-atorvastatin with, for example, Amifostine, Apalutamide, Atazanavir. The full list is on the Amlodipine-atorvastatin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
