Drug interactions
Amlodipine-atorvastatin + Quinupristin / dalfopristin
Severity: Moderate
Amlodipine-atorvastatin and Quinupristin / dalfopristin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quinupristin/dalfopristin inhibits CYP3A4 and may increase concentrations of CYP3A4 substrates such as amlodipine and atorvastatin. This could cause hypotension or edema from amlodipine and raise the risk of statin-related myopathy.
What this interaction means in plain words
Amlodipine-atorvastatin and Quinupristin / dalfopristin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of CYP3A4-mediated metabolism of amlodipine and atorvastatin.
What to do
Monitor blood pressure during the antibiotic course and ask the patient to report muscle pain or weakness. Consider temporarily holding atorvastatin if symptoms develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-atorvastatin
Frequently asked questions
Can I take Amlodipine-atorvastatin with Quinupristin / dalfopristin?
MediHelp rates the interaction as moderate. Amlodipine-atorvastatin and Quinupristin / dalfopristin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Quinupristin/dalfopristin inhibits CYP3A4 and may increase concentrations of CYP3A4 substrates such as amlodipine and atorvastatin. This could cause hypotension or edema from amlodipine and raise the risk of statin-related myopathy.
How serious is the interaction between Amlodipine-atorvastatin and Quinupristin / dalfopristin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure during the antibiotic course and ask the patient to report muscle pain or weakness. Consider temporarily holding atorvastatin if symptoms develop.
What other medicines interact with Amlodipine-atorvastatin?
MediHelp also lists interactions of Amlodipine-atorvastatin with, for example, Amifostine, Apalutamide, Atazanavir. The full list is on the Amlodipine-atorvastatin page.
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