Drug interactions
Amlodipine-atorvastatin + Rifampin
Severity: Moderate
Amlodipine-atorvastatin and Rifampin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifampin is a potent CYP3A4 inducer and substantially reduces amlodipine and atorvastatin exposure. This can cause loss of blood pressure and lipid control.
What this interaction means in plain words
Amlodipine-atorvastatin and Rifampin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Induction of CYP3A4 (and transporters) increases metabolism of both drugs.
What to do
Monitor blood pressure and lipids and increase doses as needed. If atorvastatin is used, give it at the same time as rifampin rather than separated, and recheck after rifampin is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-atorvastatin
Frequently asked questions
Can I take Amlodipine-atorvastatin with Rifampin?
MediHelp rates the interaction as moderate. Amlodipine-atorvastatin and Rifampin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rifampin is a potent CYP3A4 inducer and substantially reduces amlodipine and atorvastatin exposure. This can cause loss of blood pressure and lipid control.
How serious is the interaction between Amlodipine-atorvastatin and Rifampin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and lipids and increase doses as needed. If atorvastatin is used, give it at the same time as rifampin rather than separated, and recheck after rifampin is stopped.
What other medicines interact with Amlodipine-atorvastatin?
MediHelp also lists interactions of Amlodipine-atorvastatin with, for example, Amifostine, Apalutamide, Atazanavir. The full list is on the Amlodipine-atorvastatin page.
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