Drug interactions
Amlodipine-benazepril + Amobarbital
Severity: Moderate
Amlodipine-benazepril and Amobarbital: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Barbiturates can lower blood pressure and cause orthostatic hypotension, adding to the effect of antihypertensives. Amobarbital also induces CYP3A4 and may reduce amlodipine levels.
What this interaction means in plain words
Amlodipine-benazepril and Amobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-benazepril belongs to Cardiovascular; Amobarbital belongs to Central Nervous System.
Why it happens
Additive CNS and vasodilatory hypotensive effects, with enzyme induction possibly lowering amlodipine exposure.
What to do
Monitor blood pressure and adjust antihypertensive doses with amobarbital start or stop. Counsel about dizziness and sedation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-benazepril
- Aliskiren + Amlodipine-benazepril Contraindicated
- Amlodipine-benazepril + Sacubitril / valsartan Contraindicated
- Aldesleukin + Amlodipine-benazepril Major
- Amifostine + Amlodipine-benazepril Major
- Amiloride + Amlodipine-benazepril Major
- Amlodipine-benazepril + Azilsartan Major
Other interactions of Amobarbital
- Amobarbital + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Amobarbital + Doravirine Contraindicated
- Amobarbital + Elbasvir / grazoprevir Contraindicated
- Amobarbital + Isavuconazonium Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amobarbital + Lonafarnib Contraindicated
Frequently asked questions
Can I take Amlodipine-benazepril with Amobarbital?
MediHelp rates the interaction as moderate. Amlodipine-benazepril and Amobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Barbiturates can lower blood pressure and cause orthostatic hypotension, adding to the effect of antihypertensives. Amobarbital also induces CYP3A4 and may reduce amlodipine levels.
How serious is the interaction between Amlodipine-benazepril and Amobarbital?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and adjust antihypertensive doses with amobarbital start or stop. Counsel about dizziness and sedation.
What other medicines interact with Amlodipine-benazepril?
MediHelp also lists interactions of Amlodipine-benazepril with, for example, Aliskiren, Sacubitril / valsartan, Aldesleukin. The full list is on the Amlodipine-benazepril page.
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