Drug interactions
Amlodipine-benazepril + Atogepant
Severity: Minor
Amlodipine-benazepril and Atogepant: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Atogepant is metabolized by CYP3A4, and amlodipine is only a weak CYP3A4 inhibitor. Any rise in atogepant exposure is likely small and clinically insignificant.
What this interaction means in plain words
Amlodipine-benazepril and Atogepant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amlodipine-benazepril belongs to Cardiovascular; Atogepant belongs to Central Nervous System.
Why it happens
Weak inhibition of CYP3A4-mediated atogepant metabolism by amlodipine.
What to do
No dose adjustment is usually required; monitor for atogepant adverse effects such as constipation and nausea.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amlodipine-benazepril
- Aliskiren + Amlodipine-benazepril Contraindicated
- Amlodipine-benazepril + Sacubitril / valsartan Contraindicated
- Aldesleukin + Amlodipine-benazepril Major
- Amifostine + Amlodipine-benazepril Major
- Amiloride + Amlodipine-benazepril Major
- Amlodipine-benazepril + Azilsartan Major
Other interactions of Atogepant
- Amobarbital + Atogepant Moderate
- Apalutamide + Atogepant Moderate
- Aprepitant + Atogepant Moderate
- Armodafinil + Atogepant Moderate
- Atogepant + Bosentan Moderate
- Atogepant + Carbamazepine Moderate
Frequently asked questions
Can I take Amlodipine-benazepril with Atogepant?
MediHelp rates the interaction as minor. Amlodipine-benazepril and Atogepant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Atogepant is metabolized by CYP3A4, and amlodipine is only a weak CYP3A4 inhibitor. Any rise in atogepant exposure is likely small and clinically insignificant.
How serious is the interaction between Amlodipine-benazepril and Atogepant?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is usually required; monitor for atogepant adverse effects such as constipation and nausea.
What other medicines interact with Amlodipine-benazepril?
MediHelp also lists interactions of Amlodipine-benazepril with, for example, Aliskiren, Sacubitril / valsartan, Aldesleukin. The full list is on the Amlodipine-benazepril page.
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