Drug interactions
Amlodipine-benazepril + Avapritinib
Severity: Minor
Amlodipine-benazepril and Avapritinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Avapritinib is a CYP3A4 substrate, and amlodipine is a weak CYP3A4 inhibitor that is unlikely to raise avapritinib levels meaningfully. Only strong or moderate inhibitors require avoidance or dose reduction per labeling.
What this interaction means in plain words
Amlodipine-benazepril and Avapritinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amlodipine-benazepril belongs to Cardiovascular; Avapritinib belongs to Oncology.
Why it happens
Weak CYP3A4 inhibition by amlodipine may slightly decrease avapritinib clearance.
What to do
No dose change is needed; monitor for avapritinib adverse effects such as cognitive effects, edema and bleeding.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amlodipine-benazepril
- Aliskiren + Amlodipine-benazepril Contraindicated
- Amlodipine-benazepril + Sacubitril / valsartan Contraindicated
- Aldesleukin + Amlodipine-benazepril Major
- Amifostine + Amlodipine-benazepril Major
- Amiloride + Amlodipine-benazepril Major
- Amlodipine-benazepril + Azilsartan Major
Other interactions of Avapritinib
Frequently asked questions
Can I take Amlodipine-benazepril with Avapritinib?
MediHelp rates the interaction as minor. Amlodipine-benazepril and Avapritinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Avapritinib is a CYP3A4 substrate, and amlodipine is a weak CYP3A4 inhibitor that is unlikely to raise avapritinib levels meaningfully. Only strong or moderate inhibitors require avoidance or dose reduction per labeling.
How serious is the interaction between Amlodipine-benazepril and Avapritinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is needed; monitor for avapritinib adverse effects such as cognitive effects, edema and bleeding.
What other medicines interact with Amlodipine-benazepril?
MediHelp also lists interactions of Amlodipine-benazepril with, for example, Aliskiren, Sacubitril / valsartan, Aldesleukin. The full list is on the Amlodipine-benazepril page.
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