Drug interactions
Amlodipine-benazepril + Bortezomib
Severity: Moderate
Amlodipine-benazepril and Bortezomib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bortezomib can cause hypotension, including orthostatic hypotension, and this may be worsened by antihypertensives such as amlodipine and benazepril. Patients with dehydration or a history of syncope are at greater risk.
What this interaction means in plain words
Amlodipine-benazepril and Bortezomib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-benazepril belongs to Cardiovascular; Bortezomib belongs to Oncology.
Why it happens
Additive hypotensive effects; bortezomib causes hypotension through autonomic and volume-related mechanisms.
What to do
Monitor blood pressure and volume status during bortezomib therapy. Consider reducing or holding antihypertensives if hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Amlodipine-benazepril and Bortezomib, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Amlodipine-benazepril
- Aliskiren + Amlodipine-benazepril Contraindicated
- Amlodipine-benazepril + Sacubitril / valsartan Contraindicated
- Aldesleukin + Amlodipine-benazepril Major
- Amifostine + Amlodipine-benazepril Major
- Amiloride + Amlodipine-benazepril Major
- Amlodipine-benazepril + Azilsartan Major
Other interactions of Bortezomib
- Apalutamide + Bortezomib Major
- Bortezomib + Carbamazepine Major
- Bortezomib + Etrasimod Major
- Bortezomib + Fosphenytoin Major
- Bortezomib + Idelalisib Major
- Bortezomib + Lonafarnib Major
Frequently asked questions
Can I take Amlodipine-benazepril with Bortezomib?
MediHelp rates the interaction as moderate. Amlodipine-benazepril and Bortezomib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bortezomib can cause hypotension, including orthostatic hypotension, and this may be worsened by antihypertensives such as amlodipine and benazepril. Patients with dehydration or a history of syncope are at greater risk.
How serious is the interaction between Amlodipine-benazepril and Bortezomib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and volume status during bortezomib therapy. Consider reducing or holding antihypertensives if hypotension occurs.
What other medicines interact with Amlodipine-benazepril?
MediHelp also lists interactions of Amlodipine-benazepril with, for example, Aliskiren, Sacubitril / valsartan, Aldesleukin. The full list is on the Amlodipine-benazepril page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
