Drug interactions
Amlodipine-benazepril + Bosentan
Severity: Minor
Amlodipine-benazepril and Bosentan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bosentan is a CYP3A4 inducer and may modestly lower amlodipine exposure, reducing its effect. Bosentan itself also lowers blood pressure, so the net effect on control is variable.
What this interaction means in plain words
Amlodipine-benazepril and Bosentan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amlodipine-benazepril belongs to Cardiovascular; Bosentan belongs to Miscellaneous.
Why it happens
Induction of CYP3A4 by bosentan increases amlodipine metabolism.
What to do
Monitor blood pressure when bosentan is started, changed or stopped. Titrate amlodipine as needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amlodipine-benazepril
- Aliskiren + Amlodipine-benazepril Contraindicated
- Amlodipine-benazepril + Sacubitril / valsartan Contraindicated
- Aldesleukin + Amlodipine-benazepril Major
- Amifostine + Amlodipine-benazepril Major
- Amiloride + Amlodipine-benazepril Major
- Amlodipine-benazepril + Azilsartan Major
Other interactions of Bosentan
- Bosentan + Cyclosporin Contraindicated
- Bosentan + Cyclosporine Contraindicated
- Bosentan + Glyburide Contraindicated
- Bosentan + Glyburide-metformin Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Bosentan + Sparsentan Contraindicated
Frequently asked questions
Can I take Amlodipine-benazepril with Bosentan?
MediHelp rates the interaction as minor. Amlodipine-benazepril and Bosentan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Bosentan is a CYP3A4 inducer and may modestly lower amlodipine exposure, reducing its effect. Bosentan itself also lowers blood pressure, so the net effect on control is variable.
How serious is the interaction between Amlodipine-benazepril and Bosentan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure when bosentan is started, changed or stopped. Titrate amlodipine as needed.
What other medicines interact with Amlodipine-benazepril?
MediHelp also lists interactions of Amlodipine-benazepril with, for example, Aliskiren, Sacubitril / valsartan, Aldesleukin. The full list is on the Amlodipine-benazepril page.
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