Drug interactions
Amlodipine-benazepril + Clarithromycin
Severity: Moderate
Amlodipine-benazepril and Clarithromycin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clarithromycin inhibits CYP3A4 and raises amlodipine concentrations, which can cause hypotension, edema and bradycardia. Observational data link clarithromycin with calcium channel blockers to acute kidney injury and hypotension, especially in older patients.
What this interaction means in plain words
Amlodipine-benazepril and Clarithromycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-benazepril belongs to Cardiovascular; Clarithromycin belongs to Anti Bacterial.
Why it happens
Inhibition of CYP3A4-mediated amlodipine metabolism by clarithromycin.
What to do
Consider an alternative antibiotic such as azithromycin where possible. If used together, monitor blood pressure and renal function, and reduce the amlodipine dose if hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-benazepril
- Aliskiren + Amlodipine-benazepril Contraindicated
- Amlodipine-benazepril + Sacubitril / valsartan Contraindicated
- Aldesleukin + Amlodipine-benazepril Major
- Amifostine + Amlodipine-benazepril Major
- Amiloride + Amlodipine-benazepril Major
- Amlodipine-benazepril + Azilsartan Major
Other interactions of Clarithromycin
- Astemizole + Clarithromycin Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Cisapride + Clarithromycin Contraindicated
- Clarithromycin + Colchicine Contraindicated
- Clarithromycin + Conivaptan Contraindicated
- Clarithromycin + Dihydroergotamine Contraindicated
Frequently asked questions
Can I take Amlodipine-benazepril with Clarithromycin?
MediHelp rates the interaction as moderate. Amlodipine-benazepril and Clarithromycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clarithromycin inhibits CYP3A4 and raises amlodipine concentrations, which can cause hypotension, edema and bradycardia. Observational data link clarithromycin with calcium channel blockers to acute kidney injury and hypotension, especially in older patients.
How serious is the interaction between Amlodipine-benazepril and Clarithromycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider an alternative antibiotic such as azithromycin where possible. If used together, monitor blood pressure and renal function, and reduce the amlodipine dose if hypotension occurs.
What other medicines interact with Amlodipine-benazepril?
MediHelp also lists interactions of Amlodipine-benazepril with, for example, Aliskiren, Sacubitril / valsartan, Aldesleukin. The full list is on the Amlodipine-benazepril page.
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