Drug interactions
Amlodipine-benazepril + Clomipramine
Severity: Moderate
Amlodipine-benazepril and Clomipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clomipramine can cause orthostatic hypotension through alpha-adrenergic blockade, which adds to the effect of benazepril and amlodipine. Falls and syncope are more likely in older patients.
What this interaction means in plain words
Amlodipine-benazepril and Clomipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-benazepril belongs to Cardiovascular; Clomipramine belongs to Central Nervous System.
Why it happens
Additive hypotensive effects from alpha-1 blockade by the tricyclic and the antihypertensives.
What to do
Monitor orthostatic blood pressure when clomipramine is started or the dose increased. Lower the dose of either drug if symptomatic hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-benazepril
- Aliskiren + Amlodipine-benazepril Contraindicated
- Amlodipine-benazepril + Sacubitril / valsartan Contraindicated
- Aldesleukin + Amlodipine-benazepril Major
- Amifostine + Amlodipine-benazepril Major
- Amiloride + Amlodipine-benazepril Major
- Amlodipine-benazepril + Azilsartan Major
Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Amlodipine-benazepril with Clomipramine?
MediHelp rates the interaction as moderate. Amlodipine-benazepril and Clomipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clomipramine can cause orthostatic hypotension through alpha-adrenergic blockade, which adds to the effect of benazepril and amlodipine. Falls and syncope are more likely in older patients.
How serious is the interaction between Amlodipine-benazepril and Clomipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor orthostatic blood pressure when clomipramine is started or the dose increased. Lower the dose of either drug if symptomatic hypotension occurs.
What other medicines interact with Amlodipine-benazepril?
MediHelp also lists interactions of Amlodipine-benazepril with, for example, Aliskiren, Sacubitril / valsartan, Aldesleukin. The full list is on the Amlodipine-benazepril page.
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