Drug interactions
Amlodipine-benazepril + Crizotinib
Severity: Moderate
Amlodipine-benazepril and Crizotinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Crizotinib inhibits CYP3A4 and may raise amlodipine concentrations, leading to hypotension and edema. Crizotinib can also cause bradycardia, which may be more problematic with higher calcium channel blocker exposure.
What this interaction means in plain words
Amlodipine-benazepril and Crizotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-benazepril belongs to Cardiovascular; Crizotinib belongs to Oncology.
Why it happens
Inhibition of CYP3A4-mediated amlodipine metabolism by crizotinib.
What to do
Monitor blood pressure, heart rate and edema, and reduce the amlodipine dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-benazepril
- Aliskiren + Amlodipine-benazepril Contraindicated
- Amlodipine-benazepril + Sacubitril / valsartan Contraindicated
- Aldesleukin + Amlodipine-benazepril Major
- Amifostine + Amlodipine-benazepril Major
- Amiloride + Amlodipine-benazepril Major
- Amlodipine-benazepril + Azilsartan Major
Other interactions of Crizotinib
- Crizotinib + Flibanserin Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Crizotinib + Lonafarnib Contraindicated
- Crizotinib + Pimozide Contraindicated
- Crizotinib + Saquinavir Contraindicated
- Crizotinib + Thioridazine Contraindicated
Frequently asked questions
Can I take Amlodipine-benazepril with Crizotinib?
MediHelp rates the interaction as moderate. Amlodipine-benazepril and Crizotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Crizotinib inhibits CYP3A4 and may raise amlodipine concentrations, leading to hypotension and edema. Crizotinib can also cause bradycardia, which may be more problematic with higher calcium channel blocker exposure.
How serious is the interaction between Amlodipine-benazepril and Crizotinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate and edema, and reduce the amlodipine dose if needed.
What other medicines interact with Amlodipine-benazepril?
MediHelp also lists interactions of Amlodipine-benazepril with, for example, Aliskiren, Sacubitril / valsartan, Aldesleukin. The full list is on the Amlodipine-benazepril page.
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