Drug interactions
Amlodipine-benazepril + Desflurane
Severity: Moderate
Amlodipine-benazepril and Desflurane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Volatile anesthetics cause vasodilation and myocardial depression, and combined with antihypertensives they can produce pronounced intraoperative hypotension. ACE inhibitors in particular are associated with refractory hypotension under anesthesia.
What this interaction means in plain words
Amlodipine-benazepril and Desflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-benazepril belongs to Cardiovascular; Desflurane belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic hypotension from anesthetic vasodilation and reduced RAAS and calcium-channel-mediated vascular tone.
What to do
Inform the anesthesia team of ACE inhibitor use, consider holding benazepril on the morning of surgery per local protocol, and have vasopressors available.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-benazepril
- Aliskiren + Amlodipine-benazepril Contraindicated
- Amlodipine-benazepril + Sacubitril / valsartan Contraindicated
- Aldesleukin + Amlodipine-benazepril Major
- Amifostine + Amlodipine-benazepril Major
- Amiloride + Amlodipine-benazepril Major
- Amlodipine-benazepril + Azilsartan Major
Other interactions of Desflurane
Frequently asked questions
Can I take Amlodipine-benazepril with Desflurane?
MediHelp rates the interaction as moderate. Amlodipine-benazepril and Desflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Volatile anesthetics cause vasodilation and myocardial depression, and combined with antihypertensives they can produce pronounced intraoperative hypotension. ACE inhibitors in particular are associated with refractory hypotension under anesthesia.
How serious is the interaction between Amlodipine-benazepril and Desflurane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Inform the anesthesia team of ACE inhibitor use, consider holding benazepril on the morning of surgery per local protocol, and have vasopressors available.
What other medicines interact with Amlodipine-benazepril?
MediHelp also lists interactions of Amlodipine-benazepril with, for example, Aliskiren, Sacubitril / valsartan, Aldesleukin. The full list is on the Amlodipine-benazepril page.
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