Drug interactions
Amlodipine-benazepril + Dexmedetomidine
Severity: Moderate
Amlodipine-benazepril and Dexmedetomidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dexmedetomidine causes sympatholysis, hypotension and bradycardia. Together with an ACE inhibitor and a calcium channel blocker, hypotension may be more pronounced, particularly during sedation or anesthesia.
What this interaction means in plain words
Amlodipine-benazepril and Dexmedetomidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-benazepril belongs to Cardiovascular; Dexmedetomidine belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic blood pressure lowering from central alpha-2 agonism plus vasodilation and RAAS inhibition.
What to do
Monitor blood pressure and heart rate continuously during dexmedetomidine infusion and titrate the dose down or treat hypotension as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-benazepril
- Aliskiren + Amlodipine-benazepril Contraindicated
- Amlodipine-benazepril + Sacubitril / valsartan Contraindicated
- Aldesleukin + Amlodipine-benazepril Major
- Amifostine + Amlodipine-benazepril Major
- Amiloride + Amlodipine-benazepril Major
- Amlodipine-benazepril + Azilsartan Major
Other interactions of Dexmedetomidine
Frequently asked questions
Can I take Amlodipine-benazepril with Dexmedetomidine?
MediHelp rates the interaction as moderate. Amlodipine-benazepril and Dexmedetomidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dexmedetomidine causes sympatholysis, hypotension and bradycardia. Together with an ACE inhibitor and a calcium channel blocker, hypotension may be more pronounced, particularly during sedation or anesthesia.
How serious is the interaction between Amlodipine-benazepril and Dexmedetomidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate continuously during dexmedetomidine infusion and titrate the dose down or treat hypotension as needed.
What other medicines interact with Amlodipine-benazepril?
MediHelp also lists interactions of Amlodipine-benazepril with, for example, Aliskiren, Sacubitril / valsartan, Aldesleukin. The full list is on the Amlodipine-benazepril page.
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