Drug interactions
Amlodipine-benazepril + Eplerenone
Severity: Major
Amlodipine-benazepril and Eplerenone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eplerenone blocks the mineralocorticoid receptor and ACE inhibitors reduce aldosterone, so both retain potassium. The combination can cause clinically significant hyperkalemia, particularly with renal impairment or diabetes.
What this interaction means in plain words
Amlodipine-benazepril and Eplerenone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amlodipine-benazepril belongs to Cardiovascular; Eplerenone belongs to Cardiovascular.
Why it happens
Additive potassium retention through mineralocorticoid receptor blockade and reduced aldosterone production.
What to do
Monitor serum potassium and renal function at baseline, within the first week and regularly thereafter; reduce or stop eplerenone if potassium rises significantly.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Amlodipine-benazepril
- Aliskiren + Amlodipine-benazepril Contraindicated
- Amlodipine-benazepril + Sacubitril / valsartan Contraindicated
- Aldesleukin + Amlodipine-benazepril Major
- Amifostine + Amlodipine-benazepril Major
- Amiloride + Amlodipine-benazepril Major
- Amlodipine-benazepril + Azilsartan Major
Other interactions of Eplerenone
- Amiloride + Eplerenone Contraindicated
- Atazanavir + Eplerenone Contraindicated
- Clarithromycin + Eplerenone Contraindicated
- Cobicistat + Eplerenone Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Eplerenone Contraindicated
- Ensitrelvir + Eplerenone Contraindicated
Frequently asked questions
Can I take Amlodipine-benazepril with Eplerenone?
MediHelp rates the interaction as major. Amlodipine-benazepril and Eplerenone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Eplerenone blocks the mineralocorticoid receptor and ACE inhibitors reduce aldosterone, so both retain potassium. The combination can cause clinically significant hyperkalemia, particularly with renal impairment or diabetes.
How serious is the interaction between Amlodipine-benazepril and Eplerenone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and renal function at baseline, within the first week and regularly thereafter; reduce or stop eplerenone if potassium rises significantly.
What other medicines interact with Amlodipine-benazepril?
MediHelp also lists interactions of Amlodipine-benazepril with, for example, Aliskiren, Sacubitril / valsartan, Aldesleukin. The full list is on the Amlodipine-benazepril page.
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