Drug interactions
Amlodipine-benazepril + Ethacrynic acid
Severity: Moderate
Amlodipine-benazepril and Ethacrynic acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Loop diuretics such as ethacrynic acid add to the blood pressure lowering of ACE inhibitors, and volume depletion can precipitate marked hypotension and acute kidney injury, especially at initiation.
What this interaction means in plain words
Amlodipine-benazepril and Ethacrynic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-benazepril belongs to Cardiovascular; Ethacrynic acid belongs to Cardiovascular.
Why it happens
Additive effects: diuretic-induced volume depletion and activation of the renin system amplify the hypotensive and renal hemodynamic effects of ACE inhibition.
What to do
Monitor blood pressure, renal function and electrolytes after starting or changing doses. Consider lowering the diuretic dose before starting benazepril in volume-depleted patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-benazepril
- Aliskiren + Amlodipine-benazepril Contraindicated
- Amlodipine-benazepril + Sacubitril / valsartan Contraindicated
- Aldesleukin + Amlodipine-benazepril Major
- Amifostine + Amlodipine-benazepril Major
- Amiloride + Amlodipine-benazepril Major
- Amlodipine-benazepril + Azilsartan Major
Other interactions of Ethacrynic acid
Frequently asked questions
Can I take Amlodipine-benazepril with Ethacrynic acid?
MediHelp rates the interaction as moderate. Amlodipine-benazepril and Ethacrynic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Loop diuretics such as ethacrynic acid add to the blood pressure lowering of ACE inhibitors, and volume depletion can precipitate marked hypotension and acute kidney injury, especially at initiation.
How serious is the interaction between Amlodipine-benazepril and Ethacrynic acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, renal function and electrolytes after starting or changing doses. Consider lowering the diuretic dose before starting benazepril in volume-depleted patients.
What other medicines interact with Amlodipine-benazepril?
MediHelp also lists interactions of Amlodipine-benazepril with, for example, Aliskiren, Sacubitril / valsartan, Aldesleukin. The full list is on the Amlodipine-benazepril page.
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