Drug interactions
Amlodipine-benazepril + Fosaprepitant
Severity: Minor
Amlodipine-benazepril and Fosaprepitant: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fosaprepitant is converted to aprepitant, which is a moderate CYP3A4 inhibitor, and amlodipine is a CYP3A4 substrate. Amlodipine exposure may rise modestly after a single short course, which could cause mild extra hypotension or peripheral edema.
What this interaction means in plain words
Amlodipine-benazepril and Fosaprepitant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amlodipine-benazepril belongs to Cardiovascular; Fosaprepitant belongs to Gastrointestinal Tract.
Why it happens
Aprepitant, the active form of fosaprepitant, inhibits CYP3A4 and reduces amlodipine clearance.
What to do
No routine dose change is needed with a single dose of fosaprepitant. Check blood pressure and watch for dizziness during the days after administration.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amlodipine-benazepril
- Aliskiren + Amlodipine-benazepril Contraindicated
- Amlodipine-benazepril + Sacubitril / valsartan Contraindicated
- Aldesleukin + Amlodipine-benazepril Major
- Amifostine + Amlodipine-benazepril Major
- Amiloride + Amlodipine-benazepril Major
- Amlodipine-benazepril + Azilsartan Major
Other interactions of Fosaprepitant
- Flibanserin + Fosaprepitant Contraindicated
- Fosaprepitant + Pimozide Contraindicated
- Alprazolam + Fosaprepitant Moderate
- Amiodarone + Fosaprepitant Moderate
- Amobarbital + Fosaprepitant Moderate
- Apalutamide + Fosaprepitant Moderate
Frequently asked questions
Can I take Amlodipine-benazepril with Fosaprepitant?
MediHelp rates the interaction as minor. Amlodipine-benazepril and Fosaprepitant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fosaprepitant is converted to aprepitant, which is a moderate CYP3A4 inhibitor, and amlodipine is a CYP3A4 substrate. Amlodipine exposure may rise modestly after a single short course, which could cause mild extra hypotension or peripheral edema.
How serious is the interaction between Amlodipine-benazepril and Fosaprepitant?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed with a single dose of fosaprepitant. Check blood pressure and watch for dizziness during the days after administration.
What other medicines interact with Amlodipine-benazepril?
MediHelp also lists interactions of Amlodipine-benazepril with, for example, Aliskiren, Sacubitril / valsartan, Aldesleukin. The full list is on the Amlodipine-benazepril page.
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