Drug interactions
Amlodipine-benazepril + Iloperidone
Severity: Moderate
Amlodipine-benazepril and Iloperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Iloperidone blocks alpha-1 adrenergic receptors and can cause orthostatic hypotension. Combined with the amlodipine and benazepril antihypertensive combination, the blood pressure lowering effect is additive, with a risk of dizziness, syncope and falls.
What this interaction means in plain words
Amlodipine-benazepril and Iloperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-benazepril belongs to Cardiovascular; Iloperidone belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic hypotension from alpha-1 blockade by iloperidone together with vasodilation by amlodipine and ACE inhibition by benazepril.
What to do
Monitor blood pressure and orthostatic symptoms, especially during iloperidone titration or when doses change. Reduce the antihypertensive dose if symptomatic hypotension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-benazepril
- Aliskiren + Amlodipine-benazepril Contraindicated
- Amlodipine-benazepril + Sacubitril / valsartan Contraindicated
- Aldesleukin + Amlodipine-benazepril Major
- Amifostine + Amlodipine-benazepril Major
- Amiloride + Amlodipine-benazepril Major
- Amlodipine-benazepril + Azilsartan Major
Other interactions of Iloperidone
- Iloperidone + Thioridazine Contraindicated
- Alfuzosin + Iloperidone Major
- Amiodarone + Iloperidone Major
- Amisulpride + Iloperidone Major
- Amitriptyline + Iloperidone Major
- Anagrelide + Iloperidone Major
Frequently asked questions
Can I take Amlodipine-benazepril with Iloperidone?
MediHelp rates the interaction as moderate. Amlodipine-benazepril and Iloperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Iloperidone blocks alpha-1 adrenergic receptors and can cause orthostatic hypotension. Combined with the amlodipine and benazepril antihypertensive combination, the blood pressure lowering effect is additive, with a risk of dizziness, syncope and falls.
How serious is the interaction between Amlodipine-benazepril and Iloperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms, especially during iloperidone titration or when doses change. Reduce the antihypertensive dose if symptomatic hypotension develops.
What other medicines interact with Amlodipine-benazepril?
MediHelp also lists interactions of Amlodipine-benazepril with, for example, Aliskiren, Sacubitril / valsartan, Aldesleukin. The full list is on the Amlodipine-benazepril page.
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