Drug interactions
Amlodipine-benazepril + Linagliptin
Severity: Moderate
Amlodipine-benazepril and Linagliptin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
DPP-4 inhibitors given with ACE inhibitors have been associated with a higher rate of angioedema. The absolute risk is low, but angioedema can compromise the airway.
What this interaction means in plain words
Amlodipine-benazepril and Linagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-benazepril belongs to Cardiovascular; Linagliptin belongs to Endocrine.
Why it happens
Both drugs reduce degradation of bradykinin and substance P, so effects may be additive; the exact mechanism is not fully established.
What to do
Counsel the patient to report swelling of the face, lips, tongue or throat immediately. Stop the ACE inhibitor if angioedema occurs and seek emergency care.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-benazepril
- Aliskiren + Amlodipine-benazepril Contraindicated
- Amlodipine-benazepril + Sacubitril / valsartan Contraindicated
- Aldesleukin + Amlodipine-benazepril Major
- Amifostine + Amlodipine-benazepril Major
- Amiloride + Amlodipine-benazepril Major
- Amlodipine-benazepril + Azilsartan Major
Other interactions of Linagliptin
- Alogliptin-pioglitazone + Linagliptin Moderate
- Amobarbital + Linagliptin Moderate
- Apalutamide + Linagliptin Moderate
- Benazepril + Linagliptin Moderate
- Bexarotene + Linagliptin Moderate
- Bosentan + Linagliptin Moderate
Frequently asked questions
Can I take Amlodipine-benazepril with Linagliptin?
MediHelp rates the interaction as moderate. Amlodipine-benazepril and Linagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. DPP-4 inhibitors given with ACE inhibitors have been associated with a higher rate of angioedema. The absolute risk is low, but angioedema can compromise the airway.
How serious is the interaction between Amlodipine-benazepril and Linagliptin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel the patient to report swelling of the face, lips, tongue or throat immediately. Stop the ACE inhibitor if angioedema occurs and seek emergency care.
What other medicines interact with Amlodipine-benazepril?
MediHelp also lists interactions of Amlodipine-benazepril with, for example, Aliskiren, Sacubitril / valsartan, Aldesleukin. The full list is on the Amlodipine-benazepril page.
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