Drug interactions
Bexarotene + Linagliptin
Severity: Moderate
Bexarotene and Linagliptin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bexarotene is a CYP3A4 inducer and may lower linagliptin concentrations, potentially weakening glucose control. The direction of effect is reduction, and the magnitude is uncertain.
What this interaction means in plain words
Bexarotene and Linagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bexarotene belongs to Oncology; Linagliptin belongs to Endocrine.
Why it happens
Induction of CYP3A4 (and possibly P-gp) by bexarotene increases linagliptin clearance.
What to do
Monitor glucose and HbA1c, and add or switch antidiabetic therapy if control deteriorates.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Linagliptin
- Alogliptin-pioglitazone + Linagliptin Moderate
- Amlodipine-benazepril + Linagliptin Moderate
- Amobarbital + Linagliptin Moderate
- Apalutamide + Linagliptin Moderate
- Benazepril + Linagliptin Moderate
- Bosentan + Linagliptin Moderate
Other interactions of Bexarotene
- Bexarotene + Gemfibrozil Major
- Bexarotene + Lorlatinib Major
- Alogliptin-pioglitazone + Bexarotene Moderate
- Amobarbital + Bexarotene Moderate
- Aprepitant + Bexarotene Moderate
- Axitinib + Bexarotene Moderate
Frequently asked questions
Can I take Bexarotene with Linagliptin?
MediHelp rates the interaction as moderate. Bexarotene and Linagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bexarotene is a CYP3A4 inducer and may lower linagliptin concentrations, potentially weakening glucose control. The direction of effect is reduction, and the magnitude is uncertain.
How serious is the interaction between Bexarotene and Linagliptin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose and HbA1c, and add or switch antidiabetic therapy if control deteriorates.
What other medicines interact with Linagliptin?
MediHelp also lists interactions of Linagliptin with, for example, Alogliptin-pioglitazone, Amlodipine-benazepril, Amobarbital. The full list is on the Linagliptin page.
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