Drug interactions
Apalutamide + Linagliptin
Severity: Moderate
Apalutamide and Linagliptin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Linagliptin is mostly eliminated unchanged, with limited CYP3A4 metabolism, but it is a P-gp substrate. Strong inducers such as apalutamide can lower its exposure and reduce glucose-lowering effect.
What this interaction means in plain words
Apalutamide and Linagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Apalutamide belongs to Endocrine; Linagliptin belongs to Endocrine.
Why it happens
Apalutamide induces CYP3A4 and P-glycoprotein, lowering linagliptin exposure.
What to do
Monitor glucose and HbA1c, and consider an alternative DPP-4 inhibitor or additional therapy if control is lost.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Linagliptin
- Alogliptin-pioglitazone + Linagliptin Moderate
- Amlodipine-benazepril + Linagliptin Moderate
- Amobarbital + Linagliptin Moderate
- Benazepril + Linagliptin Moderate
- Bexarotene + Linagliptin Moderate
- Bosentan + Linagliptin Moderate
Other interactions of Apalutamide
- Apalutamide + Cabotegravir Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Apalutamide + Doravirine Contraindicated
- Apalutamide + Elbasvir / grazoprevir Contraindicated
- Apalutamide + Ensitrelvir Contraindicated
- Apalutamide + Fostemsavir Contraindicated
Frequently asked questions
Can I take Apalutamide with Linagliptin?
MediHelp rates the interaction as moderate. Apalutamide and Linagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Linagliptin is mostly eliminated unchanged, with limited CYP3A4 metabolism, but it is a P-gp substrate. Strong inducers such as apalutamide can lower its exposure and reduce glucose-lowering effect.
How serious is the interaction between Apalutamide and Linagliptin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose and HbA1c, and consider an alternative DPP-4 inhibitor or additional therapy if control is lost.
What other medicines interact with Linagliptin?
MediHelp also lists interactions of Linagliptin with, for example, Alogliptin-pioglitazone, Amlodipine-benazepril, Amobarbital. The full list is on the Linagliptin page.
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