Drug interactions
Benazepril + Linagliptin
Severity: Moderate
Benazepril and Linagliptin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
DPP-4 inhibitors may add to the risk of angioedema in patients taking ACE inhibitors. The reaction can involve the face, lips and airway and may be serious, though most patients tolerate the combination.
What this interaction means in plain words
Benazepril and Linagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Benazepril belongs to Cardiovascular; Linagliptin belongs to Endocrine.
Why it happens
ACE inhibition reduces breakdown of bradykinin and substance P, and DPP-4 inhibition also slows their degradation, so mediators of angioedema may accumulate.
What to do
Counsel patients to seek urgent care for swelling of the face, lips, tongue or throat. Stop the offending drug if angioedema occurs and avoid rechallenge.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Benazepril
- Aliskiren + Benazepril Contraindicated
- Benazepril + Sacubitril / valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Amifostine + Benazepril Major
- Amiloride + Benazepril Major
- Amlodipine-hydrochlorothiazide-valsartan + Benazepril Major
Other interactions of Linagliptin
- Alogliptin-pioglitazone + Linagliptin Moderate
- Amlodipine-benazepril + Linagliptin Moderate
- Amobarbital + Linagliptin Moderate
- Apalutamide + Linagliptin Moderate
- Bexarotene + Linagliptin Moderate
- Bosentan + Linagliptin Moderate
Frequently asked questions
Can I take Benazepril with Linagliptin?
MediHelp rates the interaction as moderate. Benazepril and Linagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. DPP-4 inhibitors may add to the risk of angioedema in patients taking ACE inhibitors. The reaction can involve the face, lips and airway and may be serious, though most patients tolerate the combination.
How serious is the interaction between Benazepril and Linagliptin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients to seek urgent care for swelling of the face, lips, tongue or throat. Stop the offending drug if angioedema occurs and avoid rechallenge.
What other medicines interact with Benazepril?
MediHelp also lists interactions of Benazepril with, for example, Aliskiren, Sacubitril / valsartan, Sacubitril-valsartan. The full list is on the Benazepril page.
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