Drug interactions
Amlodipine-benazepril + Lomitapide
Severity: Moderate
Amlodipine-benazepril and Lomitapide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amlodipine is a weak CYP3A4 inhibitor and can raise lomitapide exposure. Higher lomitapide levels raise the risk of hepatotoxicity and gastrointestinal adverse effects.
What this interaction means in plain words
Amlodipine-benazepril and Lomitapide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-benazepril belongs to Cardiovascular; Lomitapide belongs to Cardiovascular.
Why it happens
Weak CYP3A4 inhibition by amlodipine reduces lomitapide metabolism.
What to do
Keep the lomitapide dose within labeled limits for co-administration with weak CYP3A4 inhibitors. Monitor liver enzymes and tolerability.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-benazepril
- Aliskiren + Amlodipine-benazepril Contraindicated
- Amlodipine-benazepril + Sacubitril / valsartan Contraindicated
- Aldesleukin + Amlodipine-benazepril Major
- Amifostine + Amlodipine-benazepril Major
- Amiloride + Amlodipine-benazepril Major
- Amlodipine-benazepril + Azilsartan Major
Other interactions of Lomitapide
- Aprepitant + Lomitapide Contraindicated
- Clarithromycin + Lomitapide Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Efavirenz + Lomitapide Contraindicated
- Ensitrelvir + Lomitapide Contraindicated
Frequently asked questions
Can I take Amlodipine-benazepril with Lomitapide?
MediHelp rates the interaction as moderate. Amlodipine-benazepril and Lomitapide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amlodipine is a weak CYP3A4 inhibitor and can raise lomitapide exposure. Higher lomitapide levels raise the risk of hepatotoxicity and gastrointestinal adverse effects.
How serious is the interaction between Amlodipine-benazepril and Lomitapide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Keep the lomitapide dose within labeled limits for co-administration with weak CYP3A4 inhibitors. Monitor liver enzymes and tolerability.
What other medicines interact with Amlodipine-benazepril?
MediHelp also lists interactions of Amlodipine-benazepril with, for example, Aliskiren, Sacubitril / valsartan, Aldesleukin. The full list is on the Amlodipine-benazepril page.
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