Drug interactions
Amlodipine-benazepril + Mefloquine
Severity: Moderate
Amlodipine-benazepril and Mefloquine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mefloquine can cause bradycardia and conduction abnormalities, and combining it with calcium channel blockers may add to these effects. Evidence for a pharmacokinetic rise in amlodipine is limited.
What this interaction means in plain words
Amlodipine-benazepril and Mefloquine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-benazepril belongs to Cardiovascular; Mefloquine belongs to Anti Parasitic.
Why it happens
Possible additive effects on cardiac conduction and heart rate; a pharmacokinetic mechanism is not well established.
What to do
Monitor heart rate and blood pressure, and obtain an ECG if symptoms such as palpitations or syncope occur. Consider alternative antimalarials in patients with conduction disease.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-benazepril
- Aliskiren + Amlodipine-benazepril Contraindicated
- Amlodipine-benazepril + Sacubitril / valsartan Contraindicated
- Aldesleukin + Amlodipine-benazepril Major
- Amifostine + Amlodipine-benazepril Major
- Amiloride + Amlodipine-benazepril Major
- Amlodipine-benazepril + Azilsartan Major
Other interactions of Mefloquine
- Arsenic trioxide + Mefloquine Contraindicated
- Dronedarone + Mefloquine Contraindicated
- Ibutilide + Mefloquine Contraindicated
- Levoketoconazole + Mefloquine Contraindicated
- Mefloquine + Nilotinib Contraindicated
- Mefloquine + Pimozide Contraindicated
Frequently asked questions
Can I take Amlodipine-benazepril with Mefloquine?
MediHelp rates the interaction as moderate. Amlodipine-benazepril and Mefloquine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mefloquine can cause bradycardia and conduction abnormalities, and combining it with calcium channel blockers may add to these effects. Evidence for a pharmacokinetic rise in amlodipine is limited.
How serious is the interaction between Amlodipine-benazepril and Mefloquine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and blood pressure, and obtain an ECG if symptoms such as palpitations or syncope occur. Consider alternative antimalarials in patients with conduction disease.
What other medicines interact with Amlodipine-benazepril?
MediHelp also lists interactions of Amlodipine-benazepril with, for example, Aliskiren, Sacubitril / valsartan, Aldesleukin. The full list is on the Amlodipine-benazepril page.
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