Drug interactions
Amlodipine-benazepril + Nisoldipine
Severity: Moderate
Amlodipine-benazepril and Nisoldipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amlodipine and nisoldipine are both dihydropyridine calcium channel blockers, so combining them duplicates therapy. This increases the risk of hypotension, peripheral edema, flushing and reflex tachycardia without a clear added benefit.
What this interaction means in plain words
Amlodipine-benazepril and Nisoldipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-benazepril belongs to Cardiovascular; Nisoldipine belongs to Cardiovascular.
Why it happens
Duplicate dihydropyridine L-type calcium channel blockade producing additive vasodilation.
What to do
Avoid combining two dihydropyridines; stop one and use a different drug class if more blood pressure control is needed. If both are given, monitor blood pressure and for edema.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-benazepril
- Aliskiren + Amlodipine-benazepril Contraindicated
- Amlodipine-benazepril + Sacubitril / valsartan Contraindicated
- Aldesleukin + Amlodipine-benazepril Major
- Amifostine + Amlodipine-benazepril Major
- Amiloride + Amlodipine-benazepril Major
- Amlodipine-benazepril + Azilsartan Major
Other interactions of Nisoldipine
- Itraconazole + Nisoldipine Contraindicated
- Ketoconazole + Nisoldipine Contraindicated
- Apalutamide + Nisoldipine Major
- Carbamazepine + Nisoldipine Major
- Chloramphenicol + Nisoldipine Major
- Clarithromycin + Nisoldipine Major
Frequently asked questions
Can I take Amlodipine-benazepril with Nisoldipine?
MediHelp rates the interaction as moderate. Amlodipine-benazepril and Nisoldipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amlodipine and nisoldipine are both dihydropyridine calcium channel blockers, so combining them duplicates therapy. This increases the risk of hypotension, peripheral edema, flushing and reflex tachycardia without a clear added benefit.
How serious is the interaction between Amlodipine-benazepril and Nisoldipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining two dihydropyridines; stop one and use a different drug class if more blood pressure control is needed. If both are given, monitor blood pressure and for edema.
What other medicines interact with Amlodipine-benazepril?
MediHelp also lists interactions of Amlodipine-benazepril with, for example, Aliskiren, Sacubitril / valsartan, Aldesleukin. The full list is on the Amlodipine-benazepril page.
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