Drug interactions
Amlodipine-benazepril + Nitroglycerin
Severity: Moderate
Amlodipine-benazepril and Nitroglycerin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nitroglycerin is a potent vasodilator, and combining it with antihypertensives such as amlodipine and benazepril adds to the fall in blood pressure. Patients may develop dizziness, syncope or reduced organ perfusion.
What this interaction means in plain words
Amlodipine-benazepril and Nitroglycerin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-benazepril belongs to Cardiovascular; Nitroglycerin belongs to Cardiovascular.
Why it happens
Additive vasodilation and blood pressure lowering through different mechanisms.
What to do
Monitor blood pressure closely, particularly with IV nitroglycerin, and adjust the nitrate infusion or antihypertensive doses accordingly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-benazepril
- Aliskiren + Amlodipine-benazepril Contraindicated
- Amlodipine-benazepril + Sacubitril / valsartan Contraindicated
- Aldesleukin + Amlodipine-benazepril Major
- Amifostine + Amlodipine-benazepril Major
- Amiloride + Amlodipine-benazepril Major
- Amlodipine-benazepril + Azilsartan Major
Other interactions of Nitroglycerin
- Avanafil + Nitroglycerin Contraindicated
- Nitroglycerin + Riociguat Contraindicated
- Nitroglycerin + Sildenafil Contraindicated
- Nitroglycerin + Tadalafil Contraindicated
- Nitroglycerin + Vardenafil Contraindicated
- Dihydroergotamine intranasal + Nitroglycerin Major
Frequently asked questions
Can I take Amlodipine-benazepril with Nitroglycerin?
MediHelp rates the interaction as moderate. Amlodipine-benazepril and Nitroglycerin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nitroglycerin is a potent vasodilator, and combining it with antihypertensives such as amlodipine and benazepril adds to the fall in blood pressure. Patients may develop dizziness, syncope or reduced organ perfusion.
How serious is the interaction between Amlodipine-benazepril and Nitroglycerin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure closely, particularly with IV nitroglycerin, and adjust the nitrate infusion or antihypertensive doses accordingly.
What other medicines interact with Amlodipine-benazepril?
MediHelp also lists interactions of Amlodipine-benazepril with, for example, Aliskiren, Sacubitril / valsartan, Aldesleukin. The full list is on the Amlodipine-benazepril page.
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