Drug interactions
Amlodipine-benazepril + Perphenazine
Severity: Minor
Amlodipine-benazepril and Perphenazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Perphenazine has alpha-adrenergic blocking activity that can cause orthostatic hypotension. This may add to the effect of the antihypertensive combination.
What this interaction means in plain words
Amlodipine-benazepril and Perphenazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amlodipine-benazepril belongs to Cardiovascular; Perphenazine belongs to Central Nervous System.
Why it happens
Additive hypotension from alpha-1 adrenergic antagonism by the phenothiazine.
What to do
Monitor blood pressure and orthostatic symptoms, especially at initiation or dose increases. Adjust doses if symptomatic.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amlodipine-benazepril
- Aliskiren + Amlodipine-benazepril Contraindicated
- Amlodipine-benazepril + Sacubitril / valsartan Contraindicated
- Aldesleukin + Amlodipine-benazepril Major
- Amifostine + Amlodipine-benazepril Major
- Amiloride + Amlodipine-benazepril Major
- Amlodipine-benazepril + Azilsartan Major
Other interactions of Perphenazine
- Ibutilide + Perphenazine Contraindicated
- Perphenazine + Pimozide Contraindicated
- Perphenazine + Thioridazine Contraindicated
- Adagrasib + Perphenazine Major
- Alfentanil + Perphenazine Major
- Amiodarone + Perphenazine Major
Frequently asked questions
Can I take Amlodipine-benazepril with Perphenazine?
MediHelp rates the interaction as minor. Amlodipine-benazepril and Perphenazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Perphenazine has alpha-adrenergic blocking activity that can cause orthostatic hypotension. This may add to the effect of the antihypertensive combination.
How serious is the interaction between Amlodipine-benazepril and Perphenazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms, especially at initiation or dose increases. Adjust doses if symptomatic.
What other medicines interact with Amlodipine-benazepril?
MediHelp also lists interactions of Amlodipine-benazepril with, for example, Aliskiren, Sacubitril / valsartan, Aldesleukin. The full list is on the Amlodipine-benazepril page.
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