Drug interactions
Amlodipine-benazepril + Tacrolimus
Severity: Moderate
Amlodipine-benazepril and Tacrolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amlodipine may modestly raise tacrolimus concentrations in some transplant patients. Benazepril may also add to tacrolimus-related hyperkalemia and reduced renal function.
What this interaction means in plain words
Amlodipine-benazepril and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-benazepril belongs to Cardiovascular; Tacrolimus belongs to Miscellaneous.
Why it happens
Amlodipine weakly inhibits CYP3A4 (tacrolimus metabolism), while ACE inhibition and calcineurin inhibition both promote hyperkalemia and renal hemodynamic changes.
What to do
Monitor tacrolimus trough levels, serum creatinine and potassium when amlodipine is started or stopped, and adjust the tacrolimus dose as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-benazepril
- Aliskiren + Amlodipine-benazepril Contraindicated
- Amlodipine-benazepril + Sacubitril / valsartan Contraindicated
- Aldesleukin + Amlodipine-benazepril Major
- Amifostine + Amlodipine-benazepril Major
- Amiloride + Amlodipine-benazepril Major
- Amlodipine-benazepril + Azilsartan Major
Other interactions of Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicated
- Bcg vaccine live + Tacrolimus Contraindicated
- Cidofovir + Tacrolimus Contraindicated
- Cyclosporin + Tacrolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicated
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicated
Frequently asked questions
Can I take Amlodipine-benazepril with Tacrolimus?
MediHelp rates the interaction as moderate. Amlodipine-benazepril and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amlodipine may modestly raise tacrolimus concentrations in some transplant patients. Benazepril may also add to tacrolimus-related hyperkalemia and reduced renal function.
How serious is the interaction between Amlodipine-benazepril and Tacrolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor tacrolimus trough levels, serum creatinine and potassium when amlodipine is started or stopped, and adjust the tacrolimus dose as needed.
What other medicines interact with Amlodipine-benazepril?
MediHelp also lists interactions of Amlodipine-benazepril with, for example, Aliskiren, Sacubitril / valsartan, Aldesleukin. The full list is on the Amlodipine-benazepril page.
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