Drug interactions
Amlodipine-benazepril + Tazemetostat
Severity: Minor
Amlodipine-benazepril and Tazemetostat: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tazemetostat is a weak CYP3A4 inducer and may modestly lower amlodipine exposure. Amlodipine is a weak CYP3A4 inhibitor, but a meaningful effect on tazemetostat is not established.
What this interaction means in plain words
Amlodipine-benazepril and Tazemetostat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amlodipine-benazepril belongs to Cardiovascular; Tazemetostat belongs to Miscellaneous.
Why it happens
Weak CYP3A4 induction by tazemetostat may increase amlodipine metabolism.
What to do
Monitor blood pressure and adjust the amlodipine dose if control is reduced.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amlodipine-benazepril
- Aliskiren + Amlodipine-benazepril Contraindicated
- Amlodipine-benazepril + Sacubitril / valsartan Contraindicated
- Aldesleukin + Amlodipine-benazepril Major
- Amifostine + Amlodipine-benazepril Major
- Amiloride + Amlodipine-benazepril Major
- Amlodipine-benazepril + Azilsartan Major
Other interactions of Tazemetostat
Frequently asked questions
Can I take Amlodipine-benazepril with Tazemetostat?
MediHelp rates the interaction as minor. Amlodipine-benazepril and Tazemetostat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tazemetostat is a weak CYP3A4 inducer and may modestly lower amlodipine exposure. Amlodipine is a weak CYP3A4 inhibitor, but a meaningful effect on tazemetostat is not established.
How serious is the interaction between Amlodipine-benazepril and Tazemetostat?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and adjust the amlodipine dose if control is reduced.
What other medicines interact with Amlodipine-benazepril?
MediHelp also lists interactions of Amlodipine-benazepril with, for example, Aliskiren, Sacubitril / valsartan, Aldesleukin. The full list is on the Amlodipine-benazepril page.
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