Drug interactions
Amlodipine-hydrochlorothiazide-valsartan + Ampicillin
Severity: Minor
Amlodipine-hydrochlorothiazide-valsartan and Ampicillin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydrochlorothiazide may slightly reduce renal elimination of ampicillin, raising its levels. This is rarely of clinical significance because ampicillin has a wide therapeutic margin.
What this interaction means in plain words
Amlodipine-hydrochlorothiazide-valsartan and Ampicillin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amlodipine-hydrochlorothiazide-valsartan belongs to Cardiovascular; Ampicillin belongs to Anti Bacterial.
Why it happens
Competition for renal tubular secretion reduces ampicillin clearance.
What to do
No routine action is needed; consider dose adjustment only when renal function is markedly impaired.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amlodipine-hydrochlorothiazide-valsartan
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan Major
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan Major
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan Major
Other interactions of Ampicillin
- Allopurinol + Ampicillin Moderate
- Ampicillin + Bcg vaccine live Moderate
- Ampicillin + Chloramphenicol Moderate
- Ampicillin + Chloroquine Moderate
- Ampicillin + Cholera vaccine Moderate
- Ampicillin + Demeclocycline Moderate
Frequently asked questions
Can I take Amlodipine-hydrochlorothiazide-valsartan with Ampicillin?
MediHelp rates the interaction as minor. Amlodipine-hydrochlorothiazide-valsartan and Ampicillin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Hydrochlorothiazide may slightly reduce renal elimination of ampicillin, raising its levels. This is rarely of clinical significance because ampicillin has a wide therapeutic margin.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Ampicillin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action is needed; consider dose adjustment only when renal function is markedly impaired.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
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