Drug interactions
Amlodipine-hydrochlorothiazide-valsartan + Atazanavir
Severity: Moderate
Amlodipine-hydrochlorothiazide-valsartan and Atazanavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Atazanavir inhibits CYP3A4 and can raise amlodipine concentrations, increasing the likelihood of hypotension, edema and dizziness. Labeling suggests considering a lower amlodipine dose with atazanavir.
What this interaction means in plain words
Amlodipine-hydrochlorothiazide-valsartan and Atazanavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-hydrochlorothiazide-valsartan belongs to Cardiovascular; Atazanavir belongs to Anti Virals.
Why it happens
Inhibition of CYP3A4-mediated amlodipine metabolism.
What to do
Monitor blood pressure and edema, and consider starting with a reduced amlodipine dose. Since this is a fixed-dose combination, a separate-component regimen may be needed to allow titration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-hydrochlorothiazide-valsartan
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan Major
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan Major
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan Major
Other interactions of Atazanavir
- Alfuzosin + Atazanavir Contraindicated
- Atazanavir + Avanafil Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Atazanavir + Eplerenone Contraindicated
- Atazanavir + Ergotamine Contraindicated
Frequently asked questions
Can I take Amlodipine-hydrochlorothiazide-valsartan with Atazanavir?
MediHelp rates the interaction as moderate. Amlodipine-hydrochlorothiazide-valsartan and Atazanavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Atazanavir inhibits CYP3A4 and can raise amlodipine concentrations, increasing the likelihood of hypotension, edema and dizziness. Labeling suggests considering a lower amlodipine dose with atazanavir.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Atazanavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and edema, and consider starting with a reduced amlodipine dose. Since this is a fixed-dose combination, a separate-component regimen may be needed to allow titration.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
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