Drug interactions
Amlodipine-hydrochlorothiazide-valsartan + Atorvastatin
Severity: Minor
Amlodipine-hydrochlorothiazide-valsartan and Atorvastatin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amlodipine causes a small increase in atorvastatin exposure, which is not usually clinically significant. Valsartan is an OATP1B1 substrate, but a meaningful interaction with atorvastatin has not been established.
What this interaction means in plain words
Amlodipine-hydrochlorothiazide-valsartan and Atorvastatin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amlodipine-hydrochlorothiazide-valsartan belongs to Cardiovascular; Atorvastatin belongs to Cardiovascular.
Why it happens
Possible minor transporter or CYP3A4 effects.
What to do
No routine action is needed. Report muscle pain or weakness promptly.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amlodipine-hydrochlorothiazide-valsartan
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan Major
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan Major
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan Major
Other interactions of Atorvastatin
- Atorvastatin + Tipranavir Contraindicated
- Atazanavir + Atorvastatin Major
- Atorvastatin + Clarithromycin Major
- Atorvastatin + Cobicistat Major
- Atorvastatin + Cyclosporin Major
- Atorvastatin + Cyclosporine Major
Frequently asked questions
Can I take Amlodipine-hydrochlorothiazide-valsartan with Atorvastatin?
MediHelp rates the interaction as minor. Amlodipine-hydrochlorothiazide-valsartan and Atorvastatin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Amlodipine causes a small increase in atorvastatin exposure, which is not usually clinically significant. Valsartan is an OATP1B1 substrate, but a meaningful interaction with atorvastatin has not been established.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Atorvastatin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action is needed. Report muscle pain or weakness promptly.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
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