Drug interactions
Amlodipine-hydrochlorothiazide-valsartan + Calcium acetate
Severity: Minor
Amlodipine-hydrochlorothiazide-valsartan and Calcium acetate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Calcium can blunt the blood pressure lowering effect of calcium channel blockers such as amlodipine. In oral use at usual doses this effect is small. Thiazide with calcium salts can also raise serum calcium.
What this interaction means in plain words
Amlodipine-hydrochlorothiazide-valsartan and Calcium acetate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amlodipine-hydrochlorothiazide-valsartan belongs to Cardiovascular; Calcium acetate belongs to Genitourinary.
Why it happens
Increased extracellular calcium may partly overcome calcium channel blockade, and thiazides reduce urinary calcium excretion.
What to do
Monitor blood pressure and serum calcium when starting or changing calcium doses, especially with high-dose calcium or renal impairment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amlodipine-hydrochlorothiazide-valsartan
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan Major
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan Major
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan Major
Other interactions of Calcium acetate
Frequently asked questions
Can I take Amlodipine-hydrochlorothiazide-valsartan with Calcium acetate?
MediHelp rates the interaction as minor. Amlodipine-hydrochlorothiazide-valsartan and Calcium acetate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Calcium can blunt the blood pressure lowering effect of calcium channel blockers such as amlodipine. In oral use at usual doses this effect is small. Thiazide with calcium salts can also raise serum calcium.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Calcium acetate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and serum calcium when starting or changing calcium doses, especially with high-dose calcium or renal impairment.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
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