Drug interactions
Amlodipine-hydrochlorothiazide-valsartan + Cefprozil
Severity: Minor
Amlodipine-hydrochlorothiazide-valsartan and Cefprozil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazides and cephalosporins can compete for renal tubular secretion, which may modestly raise cefprozil concentrations. Cefprozil is a drug with a wide safety margin, so the effect is rarely clinically significant, though dosing in renal impairment should be considered.
What this interaction means in plain words
Amlodipine-hydrochlorothiazide-valsartan and Cefprozil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amlodipine-hydrochlorothiazide-valsartan belongs to Cardiovascular; Cefprozil belongs to Anti Bacterial.
Why it happens
Competition for renal tubular organic anion secretion reduces cefprozil clearance.
What to do
No dose change is usually needed; consider cefprozil dose adjustment only if renal function is significantly reduced.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amlodipine-hydrochlorothiazide-valsartan
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan Major
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan Major
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan Major
Other interactions of Cefprozil
- Amikacin + Cefprozil Moderate
- Bcg vaccine live + Cefprozil Moderate
- Cefprozil + Cholera vaccine Moderate
- Cefprozil + Gentamicin Moderate
- Cefprozil + Microbiota Moderate
- Cefprozil + Plazomicin Moderate
Frequently asked questions
Can I take Amlodipine-hydrochlorothiazide-valsartan with Cefprozil?
MediHelp rates the interaction as minor. Amlodipine-hydrochlorothiazide-valsartan and Cefprozil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Thiazides and cephalosporins can compete for renal tubular secretion, which may modestly raise cefprozil concentrations. Cefprozil is a drug with a wide safety margin, so the effect is rarely clinically significant, though dosing in renal impairment should be considered.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Cefprozil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed; consider cefprozil dose adjustment only if renal function is significantly reduced.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
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