Drug interactions
Amlodipine-hydrochlorothiazide-valsartan + Celecoxib
Severity: Moderate
Amlodipine-hydrochlorothiazide-valsartan and Celecoxib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs such as celecoxib can blunt the antihypertensive effect of ARBs and thiazides and, in combination with them, increase the risk of acute kidney injury, particularly in elderly or volume-depleted patients. Hyperkalemia may also occur because of reduced renal prostaglandin-mediated effects on potassium handling.
What this interaction means in plain words
Amlodipine-hydrochlorothiazide-valsartan and Celecoxib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-hydrochlorothiazide-valsartan belongs to Cardiovascular; Celecoxib belongs to Musculoskeletal.
Why it happens
Inhibition of renal prostaglandin synthesis causes sodium and water retention and lowers renal perfusion, opposing the antihypertensive agents and adding to renal hemodynamic stress.
What to do
Use the lowest effective celecoxib dose for the shortest period and ensure adequate hydration. Monitor blood pressure, serum creatinine and potassium, especially after starting therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-hydrochlorothiazide-valsartan
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan Major
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan Major
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan Major
Other interactions of Celecoxib
- Celecoxib + Ketorolac Contraindicated
- Celecoxib + Ketorolac intranasal Contraindicated
- Aceclofenac + Celecoxib Major
- Acemetacin + Celecoxib Major
- Amiloride + Celecoxib Major
- Apixaban + Celecoxib Major
Frequently asked questions
Can I take Amlodipine-hydrochlorothiazide-valsartan with Celecoxib?
MediHelp rates the interaction as moderate. Amlodipine-hydrochlorothiazide-valsartan and Celecoxib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs such as celecoxib can blunt the antihypertensive effect of ARBs and thiazides and, in combination with them, increase the risk of acute kidney injury, particularly in elderly or volume-depleted patients. Hyperkalemia may also occur because of reduced renal prostaglandin-mediated effects on potassium handling.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Celecoxib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective celecoxib dose for the shortest period and ensure adequate hydration. Monitor blood pressure, serum creatinine and potassium, especially after starting therapy.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
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