Drug interactions
Amlodipine-hydrochlorothiazide-valsartan + Chloramphenicol
Severity: Moderate
Amlodipine-hydrochlorothiazide-valsartan and Chloramphenicol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chloramphenicol can inhibit CYP3A4 and may raise amlodipine concentrations. This could cause excess vasodilation with hypotension and peripheral edema, though clinical data specific to amlodipine are limited.
What this interaction means in plain words
Amlodipine-hydrochlorothiazide-valsartan and Chloramphenicol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-hydrochlorothiazide-valsartan belongs to Cardiovascular; Chloramphenicol belongs to Anti Bacterial.
Why it happens
Inhibition of CYP3A4-mediated metabolism of amlodipine by chloramphenicol, reducing its clearance.
What to do
Monitor blood pressure and for edema or dizziness during chloramphenicol therapy. Reduce the amlodipine dose if hypotension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-hydrochlorothiazide-valsartan
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan Major
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan Major
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan Major
Other interactions of Chloramphenicol
Frequently asked questions
Can I take Amlodipine-hydrochlorothiazide-valsartan with Chloramphenicol?
MediHelp rates the interaction as moderate. Amlodipine-hydrochlorothiazide-valsartan and Chloramphenicol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chloramphenicol can inhibit CYP3A4 and may raise amlodipine concentrations. This could cause excess vasodilation with hypotension and peripheral edema, though clinical data specific to amlodipine are limited.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Chloramphenicol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and for edema or dizziness during chloramphenicol therapy. Reduce the amlodipine dose if hypotension develops.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
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