Drug interactions
Amlodipine-hydrochlorothiazide-valsartan + Cholestyramine
Severity: Moderate
Amlodipine-hydrochlorothiazide-valsartan and Cholestyramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cholestyramine binds hydrochlorothiazide in the gut and markedly reduces its absorption, weakening diuretic and antihypertensive effect. Other co-administered oral drugs may be affected as well, with valsartan absorption possibly also reduced.
What this interaction means in plain words
Amlodipine-hydrochlorothiazide-valsartan and Cholestyramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-hydrochlorothiazide-valsartan belongs to Cardiovascular; Cholestyramine belongs to Cardiovascular.
Why it happens
Anion-exchange resin binding of hydrochlorothiazide in the gastrointestinal tract decreases its absorption.
What to do
Give the combination tablet at least 4 hours before or 4 to 6 hours after cholestyramine. Monitor blood pressure if the dosing schedule changes.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-hydrochlorothiazide-valsartan
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan Major
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan Major
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan Major
Other interactions of Cholestyramine
Frequently asked questions
Can I take Amlodipine-hydrochlorothiazide-valsartan with Cholestyramine?
MediHelp rates the interaction as moderate. Amlodipine-hydrochlorothiazide-valsartan and Cholestyramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cholestyramine binds hydrochlorothiazide in the gut and markedly reduces its absorption, weakening diuretic and antihypertensive effect. Other co-administered oral drugs may be affected as well, with valsartan absorption possibly also reduced.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Cholestyramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give the combination tablet at least 4 hours before or 4 to 6 hours after cholestyramine. Monitor blood pressure if the dosing schedule changes.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
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